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The existence of large and small ribosomal subunits has been demonstrated in shadowed (7) and negatively stained (9, 17, 18) ribosomal preparations . Positively stained preparations have failed to demonstrate this subunit structure but instead reveal a 20-40 A substructure in ribosomes (9, 12) . Although the evidence in some studies (13) on intact cells has indicated ribosomal subunits, ribosomes in intact cells generally do not demonstrate a subunit structure . On the hases of the large subunit attachment of ribosomes to endoplasmic reticulum membranes (13, 17, 18) and of the unidirectional transport of protein into endoplasmic reticulum cisternae (15), it has been suggested that nascent polypeptide chains might pass into the intracisternal space through a channel in the large subunit (15) . In the present study, observations on positively stained, intact liver cells reveal structural details in ribosomes identical to those previously observed, or suggested, in studies of ribosomal preparations and in a few studies of intact cells. Micrographs detailing these structures were chosen from regions of hepatocytes containing predominantly granular endoplasmic reticulum .

RIBOSOME SUBSTRUCTURE IN INTACT MOUSE LIVER CELLS