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Recen t studies on cytoplasmic microtubules have provided evidence for regarding t hem as gel components susceptible to solational weakenings. Micro tubule s tructure in various cell types has been shown to be sensitive to temperature , pH, pressure, and other envi ronmenta l conditions (Masser and Philpott , 1966; Ti lney et al., 1966; Ti lney and Porter, 1967). In the present work, the sciatic nerve of the toad was studied to determine whe ther low tempera tures may also affect the integrity of neurona l microtubules. These microtubules were found to be sensitive to t empera tu re and not to be dependen t on the per ikaryon for re-formation. M A T E R I A L A N D M E T H O D S

MICROTUBULES IN THE NERVE FIBERS OF THE TOAD BUFO ARENARUM HENSEL