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Shy et al. (10) described the case of a 4 yr old girl suffering from a familial, nonprogressive weakness of the proximal muscles of the extremities. Upon biopsy the muscle fibers were found to contain elongate, rodlike bodies with a fibrillar structure and a fine periodic cross-striation. This condition was considered to be a new congenital myopathy and was given the name "nemaline myopathy," a term intended to be descriptive of the characteristic thread or rodlike inclusions found in biopsies. Several other cases have since been reported (Engel et al., reference 1; Gonatas et al., reference 3; Price et al., reference 8; Spiro and Kennedy, reference 11), and further study of electron micrographs has shown that, in addition to the rodlike inclusions, the Z bands often exhibit fusiform expansions up to several times the no.mal width of this band. These unusually broad Z bands are reported to exhibit a pattern of fine, transverse striations, -175 A apart, similar to those seen in the inclusions. Because this form of pathology of skeletal muscle is now attracting considerable attention, both among students of muscle fine structure and among clinicians who consider it to be pathognomonic of nemaline myopathy, it is thought to be of some importance to descriLe a similar disturbance of Z band structure observed some time ago in certain fibers of the right ventricular papillary muscle in the hearts of aging but otherwise healthy cats. The occasional observation of periodic structure in the Z band casts doubt upon one of the interpretations of its normal organization and provides further support for the suggestion that at least part of the tropomyosin of striated muscle is localized in the Z band.

THE SPORADIC OCCURRENCE IN CARDIAC MUSCLE OF ANOMALOUS Z BANDS EXHIBITING A PERIODIC STRUCTURE SUGGESTIVE OF TROPOMYOSIN