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The heterogeneity of the endoplasmic reticulum (ER) is well established in cell biology. To a large extent, however, the differences among ER domains (such as the nuclear envelope and the rough- and smooth-surfaced cisternae) are believed to reflect their different involvement in the synthesis,

The Heterogeneity of ER Ca2+ Stores Has a Key Role in Nonmuscle Cell Signaling and Function