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Wi th new methods of prepar ing th in sections for electron microscopy, glycogen has been identified in the cytoplasm of liver cells as dense particles of various sizes (3, 4, 7, 9). Glycogen does not usually occur within the nucleus, bu t it has been described there in a variety of pathological conditions (1). This report concerns the appearance of glycogen in the nucleus of liver cells from a pa t ien t with glycogen storage disease, type 11 (yon Gierke's disease).

ON THE DIFFERING APPEARANCE OF INTRANUCLEAR AND CYTOPLASMIC GLYCOGEN IN LIVER CELLS IN GLYCOGEN STORAGE DISEASE