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During recent years cytoplasmic corpuscles commonly known as dense bodies, lysosomes, multivesicular bodies, cytosomes, phagosomes, and microbodies have attracted much attention (see reviews by de Duve (3) and Novikoff (5)). Probably the different terms cover the same concept in several cases, but it is not clear what the exact relationship between these various corpuscles is, and whether they bear a possible relationship to other cell components. During a study of the epithelium of the small intestine in newborn rats we found in several instances cytoplasmic bodies containing mitochondria, vesicles, ribosomes, and rough surfaced endoplasmic reticulum. Mitochondria and what looks like mitochondrial residue have been observed earlier in cytoplasmic bodies in the epithelium of the small intestine of adult mice (11). In the proximal tubule cells of the kidney of infant mice, Clark (2) found membrane-bounded cytoplasmic bodies and vacuoles which sometimes contained lamellar inclusions and altered mitochondria. Similar cytoplasmic vacuoles containing mitochondria in apparently varying states of disintegration have been observed by Novikoff (4) in the proximal tubule cells in experimentally produced hydronephrosis. As far as we know, bodies with incorporated rough surfaced endoplasmic reticulum have not been reported. M A T E R I A L A N D M E T H O D

the journal of cell biology/the journal of cell biology

CYTOPLASMIC BODIES CONTAINING MITOCHONDRIA, RIBOSOMES, AND ROUGH SURFACED ENDOPLASMIC MEMBRANES IN THE EPITHELIUM OF THE SMALL INTESTINE OF NEWBORN RATS