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Prader-Willi Syndrome (PWS) is characterized by hyperphagia, an extreme and persistent hunger that emerges in early childhood. We used event-related potentials (ERPs) to objectively investigate brain responses to low- and high-calorie foods, animals, and household objects in 20 satiated adolescents with PWS. Late Positive Potential (LPP) responses to food images did not differ from non-food images. Rather, we observed larger ERPs to high-calorie foods relative to animal images ( p=.001 ) in an earlier time window. These responses correlated with greater severity of hyperphagia ( p = .01 ). Thus, hyperphagia associated with PWS may be due to altered satiety regulation rather than increased motivational salience.

Food cue reward salience does not explain Hyperphagia in adolescents with Prader-Willi syndrome