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Juglans regia  is a medicinal plant widely used in traditional medicine and it. It is applied for healing a numerous ailment such us diabetes, digestive problems, hypertension, and gout diseases. This review aims to highlight the importance of  Juglans regia  as source of nutritional and bioactive compounds. Mechanisms of antimicrobial, antioxidant, anti-inflammatory, antidiabetic, and anticancer activities  of Juglans regia  leaves, fruit, septum kernels, flowers, bark, and husk have been discussed.  Juglans regia  fruits have an important nutritive value allowed by their richness in lipids and proteins. Medicinal properties of  Juglans regia  are certainly due to its bioactive compounds. Indeed,  Juglans regia  leaves, husks, flowers, bark, and roots contain several secondary metabolites including polyphenols, flavonoids, and glycosides. Pharmacological investigations reported by the literature demonstrated that  Juglans regia  exhibit different biological activities such as antioxidant, anti-inflammatory, anti-diabetic, antitumoral, antifungal, and antibacterial effects,  in vitro ,  in vivo  and in clinical trials. Mechanisms of bioactive compound action include ROS neutralization, proinflammatory mediators and enzyme inhibition, insulin levels increase, regulation of apoptosis, and cell cycle disruption. Biological properties were remarkably correlated with bioactive compounds containing in  Juglans regia . Therefore, with its important nutritive values and its bioactive compounds,  Juglans regia  could be considered as a relevant functional food.

food reviews international

A Review on Medicinal Uses, Nutritional Value, and Antimicrobial, Antioxidant, Anti-Inflammatory, Antidiabetic, and Anticancer Potential Related to Bioactive Compounds of  J. regia