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Breast cancer is the most commonly diagnosed oncological malignancy in women. The search for better treatment alternatives has placed attention on natural products. Propolis, a resinous bee product rich in polyphenols, has important anti-proliferative properties. This review describes the molecular mechanisms of propolis and several of its constituents in breast cancer, with a special focus on those involved in their anti-proliferative, pro-apoptotic and anti-metastatic activities. Their therapeutic potential in breast cancer is discussed, both individually, and in combination, identifying opportunities for future research. Synergistic effects of propolis-derived chemicals could lay the foundation for future breakthroughs in breast cancer treatment strategies.

Molecular Mechanisms of Biologically Active Compounds from Propolis in Breast Cancer: State of the Art and Future Directions