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Grape seed extract is a highly efficient natural antioxidant, mainly due to proanthocyanidin. Grape seed proanthocyanidin (GSP) confers antitumor, antiradiation, antibacterial and anti-inflammatory activities, protection of cardiovascular and cerebrovascular systems, and visual function improvement, among other biological activities. However, GSP is sensitive to light and heat, and is easily affected by pH, oxygen levels, etc., complicating its extraction and application. This article analyzes the advantages and disadvantages of different extraction processes, summarizes the applicable extraction methods under different conditions, and provides a theoretical basis for GSP processing, while emphasizing GSP’s excellent biological activity and the current status of its development and utilization in food industry.

Prospects for Proanthocyanidins from Grape Seed: Extraction Technologies and Diverse Bioactivity