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Some cervical cancer patients show poor response to neoadjuvant chemotherapy. Although it has been demonstrated that macroautophagy/autophagy contributes to the poor chemosensitivity, the underlying mechanism has not yet been fully clarified. In this autophagy punctum, we discuss our recent findings about the mechanism of SOX6-induced autophagy and its potential significance in the platinum-based chemotherapy of cervical cancer.

SOX6-MAP4K4 pathway induces autophagy and contributes to the reduced chemosensitivity of cervical cancer