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Previous studies revealed that both  Helicobacter pylori  infection and some cytokine gene polymorphisms are risk factors for gastric diseases. The association between  H. pylori  and gene polymorphisms is worth exploring .  Here we conducted a case–control study and systematically evaluate on association between  H. pylori  infection and  IL4, TNFA,  and  IL10  polymorphisms in a Chinese Han population in northwestern China, where gastric cancer is the major burden on the health and the leading cause of death in local community. The Sequenom MassArray platform was used to screen the genotypes and  14 C-urea breath test was employed to determine  H. pylori  infection status of 705 participants of the local rural residents. Significant association between  H. pylori  infection and the  IL4  rs34142320 polymorphism was observed in the dominant model (OR =  0 .57, 95% CI =  0 .40–0.80,  P  =  0 .030). No significant association was found between  IL4  rs2243250,  TNFA  rs1800630,  TNFA  rs1800629,  TNFA  rs1799964,  IL10  rs1800871,  IL10  rs1800896 and  H. pylori  infection .  Haplotype analysis showed that T-DEL and G-C haplotypes of the observed  IL4 SNPs  were significantly associated with  H. pylori  infection. Our analysis demonstrated that the  IL4  rs34142320 polymorphism has a protective effect on  H. pylori  infection in Chinese Han population.

IL4 rs34142320 polymorphism is associated with susceptibility to Helicobacter pylori infection in Chinese Han population in northwestern China