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The continuous application of pesticides leads to several harmful effects on the ecosystem and get accumulated in the food chain. To regulate the toxicity of pesticides there are several strategies available. In relation to this, the endogenous as well as exogenous role of salicylic acid in pesticide regulation is less overviewed. To regulate the pesticide stress, in presence of salicylic acid, the genes, and proteins related to reduced glutathione (GSH) metabolism, biosynthesis of secondary metabolites, glyoxylate, and dicarboxylate metabolism get upregulated and are found to be more differentially expressed for pesticide detoxification. Salicylic acid regulates pesticide toxicity by activating gene expression of  P450 , antioxidant enzymes, ABC transporters subfamilies to form a defense network. In this context, the present review tries to comprehend the pesticide detoxification processes involving salicylic acid to regulate the stress caused thereby in plants and further utilize this strategy for wider application.

An overview on the modulation of pesticide detoxification mechanism via salicylic acid in the plants