English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Green synthesis of silver nanoparticles using water extract of  Bistorta officinalis  (BO/Ag-NPs) and evaluation of toxicity and its pro-apoptotic effects. BO/Ag-NPs were synthesized and characterized by DLS, FTIR, XRD, EDX, TEM and FESEM. Then, toxicity and apoptotic effect of BO/Ag-NPs were assessed by MTT, qPCR, flow cytometry and AO/PI methods. Spherical BO/Ag-NPs with a size of 29 nm, PDI of 0.3 and ζ potential of −27.06 mV were synthesized. Medium concentrations of BO/Ag-NPs on MDA-mb231 and HDF cells were reported about 6.1 and &gt;50 µg.ml respectively. Increase the rate of apoptotic cells in AO/PI staining and flow cytometry and upregulation of caspase 3,9 and Bax genes and down regulation of Bcl-2 gene confirmed the activated of intrinsic pathway in BO/Ag-NPs treated cells. Due to the biological effects of BO/Ag-NP, these nanoparticles could be a promising factor in cancer therapy.

Green fabrication of silver nanoparticles mediated by Bistorta officinalis aqueous extract: putative mechanism for apoptosis-inducing properties