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Two new cobalt(II) coordination polymers based on H 4 bpta (H 4 bpta = 3,3′,5,5′-biphenyltetracarboxylic acid) and N-donor ligands, namely [Co 2 (1,3-bimb) 2 (bpta)]n·2 n H 2 O ( 1 ) and [Co 2 (1,4-bib) 2 (bpta)]n·2 n (H 2 O·DMF) ( 2 ), (1,4-bib = 1,4-bis(imidazol-1-yl)benzene, 1,3-bimb = 1,3-bis((1 H -imidazol-1-yl)methyl)benzene), have been obtained under solvothermal conditions. Series of biological experiments were performed for the biological activity evaluation. Firstly, the western blotting assay was performed to evaluate the inflammasome activation in the endothelial cells of retina after compound treatment. Besides, the enzyme linked immunosorbent assay (ELISA) detection kit was used to measure the down-stream production of the inflammasome activation.

Two Co(II)-coordination polymers: reducing the inflammasome activation and exerting treatment activity on age-related macular degeneration