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Staphylococcus aureus  is the most common microbe in prosthetic joint infections (PJIs). Debridement, antimicrobials, and implant retention (DAIR) are often-recommended treatment modality for acute PJIs, even though it has had relatively poor outcomes in some studies. In this study, we wanted to examine treatment results with a multidisciplinary team in a specialised centre and obtain further information for treatment decisions in acute  Staphylococcus aureus  PJIs. All consecutive haematogenous late acute and postoperative early acute hip and knee  Staphylococcus aureus  PJIs treated with DAIR during 2011–2016 were included in this retrospective study. DAIR within three weeks from symptom onset and the exchange of modular parts were required. Eighty-five acute  Staphylococcus aureus  PJIs were treated with DAIR in 83 patients: 28 late acute and 57 early acute PJIs. The late acute PJI patients were older and had malignancies more often than the early acute PJI patients. Bacteraemia was present in 50.6% of  Staphylococcus aureus  PJI patients, more often in late acute (73.1%) than in early acute (40.4%) patients ( p  = .006). The implant was retained in 80.0%: 89.3% of the late acute and 75.4% of the early acute PJIs. In 17 joints, DAIR failed and the joint had to be removed. Fourteen of these joints were successfully replaced. One infection-related death occurred. The one-year all-cause mortality rate was 3.6%. Suppressive antimicrobial treatment was given to 22 (26.5%) patients. Reasonably good treatment results for acute  Staphylococcus aureus  PJIs are achievable by DAIR in a specialised centre with a strict treatment protocol and a multidisciplinary team. If the DAIR fails, a two-stage exchange is usually still possible, with good results.

Debridement, antimicrobials, and implant retention in the treatment of late acute and early acute Staphylococcus aureus prosthetic joint infections