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Postural stability is a crucial aspect of human balance and equilibrium. One way to quantify postural stability is by analyzing variations in the center of pressure under the feet. However, there are several factors involved in quantifying postural stability, and interpreting the information they provide can be challenging, especially in the context of pathological motion. The aim of this work is to reduce the confounding effects of these factors to the extent that measurable differences in results are primarily due to a pathological condition rather than secondary factors such as procedural variations. Materials and methods: The initial research conditions were established based on theoretical aspects of human standing stability. Thirteen normal subjects (5 female and 8 male) with a mean age of 21 ± 4.97 years and a mean BMI of 25.27 ± 4.53 kg/m 2  were recruited for the study. Four investigations were conducted, including eyes closed-closed base, eyes open-closed base, eyes closed-open base, and eyes open-open base conditions. Data collection was performed using the AMTI AccuGait force plate and Balance Clinic software. Spectral characteristics, composite multiscale entropy, and conventional stability parameters were computed for both the anterior-posterior (AP) and medial-lateral (ML) directions. Results: Composite multiscale entropy shows no significant difference ( p  &gt; 0.05) in both AP and medial-lateral (ML) directions. Whereas the frequency of oscillations in ML is more sensitive than other parameters with relatively large effect size (&gt;0.9). Conclusion: The resulting set of variables provides a broad range of options for selecting specific variables related to a particular study topic. The benefit of this method is that it standardizes the analysis of the center of pressure and enables the comparability of variables gathered during various research measurements. For general standing stability measurements, composite multiscale sampling entropy is the most relevant factor that can be used to discriminate the stability state in both the anterior-posterior and medial-lateral directions.

A study of the dynamic variability of the center of pressure during standing for normal subjects