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The potential impact of depressive symptoms on neuropsychological test performance has been studied extensively yielding mixed results. Self-report depression inventories have been most often used, without a means to screen participants for response bias. Studies have also neglected to screen participants for incomplete effort in testing. In the present study, 48% of an initial sample of outpatient referrals ( N  = 247) failed to meet traditional validity criteria. The remaining participants were screened for cerebral pathology and then classified into high and low depressive symptom groups ( n s = 46) using the median score on Scale D (Depression) of the MMPI-2. The “high depression” subjects scored over 70  T  on the D scale ( MN  = 80  T ). The “low depression” subjects scored below 65  T  ( MN  = 58  T ). Age, education, and estimated intelligence were equivalent across groups. Neuropsychological test performances were compared across eight tests: Revised Category Test, Trail Making Test, Part B, Tactual Performance Test (TPT), TPT Memory and Location, Reitan-Indiana Aphasia Screening Test, Seashore Rhythm Test, and the Speech Perception Test. A MANOVA revealed no main effect for group.,  F (8,69) = 1.05,  n.s. , and univariate analyses for each test also showed no intergroup differences. The results provide evidence that these neuropsychological tests are appropriately interpreted within a framework of brain-behavior relationships irrespective of an examinee’s emotional status.

Depressive symptoms as a factor in neuropsychological test performance: MMPI-2 and selected tests of the Halstead-Reitan/Halstead-Russell Battery