English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Gleditsia  species were widely used traditionally for the treatment of GIT problems and skin diseases, especially in Chinese traditional medicine.  Gleditsia  species isolated compounds and biological activities were summarized in a previous review published in 2015. This work aims to review the isolated chemical compounds from  Gleditsia  species and their biological activities during the period from 2015 to 2021. More than eighty compounds belonging to flavonoids, triterpenoidal saponins, alkaloids, lignans or coumarins were isolated from  Gleditsia triacanthos  L. , Gleditsia sinensis  Lam. , Gleditsia capsica  Desf. , Gleditsia aquatic  Marshal , and Gleditsia japonica  Miq. during this period. Triterpenoidal saponins and flavonoids were the most abundant constituents of  Gleditsia  species. Crude extracts, fractions and isolated compounds showed diverse cytotoxic, antimicrobial, antihyperlipidemic, analgesic, antioxidant and hypoglycemic activities. Some of the possible mechanisms of actions are reported in this review such as causing apoptosis, affecting adhesion, migration and size of cancer cells and decreasing the expression of cyclooxygenase, prostaglandin E2, tumor necrosis factor- α  and interleukin (IL)-1 β . According to this review, new compounds are still being isolated from  Gleditsia  species with promising biological activities. Further studies can be conducted to explore more bioactive compounds responsible for the pharmacological activities of genus  Gleditsia  and elucidate their mechanisms of action.

Genus Gleditsia : A Phytochemical and Biological Review (2015-2020)