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This article presents a series of seven ventilator-dependent patients with pandemic influenza A (H1N1) 2009 and one with seasonal influenza at two hospitals—a government regional hospital and a private hospital—in the Ugu District, KwaZulu-Natal. The clinical features of these patients are described, and an attempt is made to highlight the problems encountered in managing such patients in a regional South African setting.

Pandemic influenza A (H1N1) 2009: a case series from intensive care units in Port Shepstone, South Africa