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Infections caused by drug-resistant bacteria are major health concerns worldwide. We successfully synthesized cephradine gold nanoparticles (Ceph-Au NPs) and cephradine silver nanoparticles (Ceph-Ag NPs) and compared their efficacy against resistant human pathogens. X-Ray diffraction (XRD), Atomic Force Microscopy (AFM) and Transmission Electron Microscopy (TEM) results showed that average particle size of Ceph-Au NPs and Ceph-Ag NPs were 7 and 12 nm, respectively. Fourier Transform Infra-red spectroscopy (FTIR) spectra revealed the conjugation of –NH 2  and –OH functional moieties with the nanoparticle (NP) surfaces. These NPs significantly inhibited the biofilm of  Streptococcus mutans  ( S. mutans)  and methicillin-resistant  Staphylococcus aureus  (MRSA) in the range of 61.25–250 µg/mL. Ceph-Au NPs are more active than Ceph-Ag NPs and can be used to treat the diseases associated with MRSA and  S. mutans.

Comparative efficacy of cephradine-loaded silver and gold nanoparticles against resistant human pathogens