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The study was conducted to assess medical staffs’ fear of receiving the fourth dose of the Coronavirus disease 2019 (COVID-19) vaccine. From December 17, 2022, to January 31, 2023, an online survey was conducted to assess the fear among medical staffs regarding the administration of the fourth dose of the COVID-19 vaccine. The participants were exclusively drawn from a tertiary grade hospital in Taizhou. Out of the 1, 832 medical staffs invited to participate in the questionnaire, a total of 613 (33.5%) provided valid responses for subsequent analysis. Among them, 81 (13.8%) expressed fear of receiving the fourth dose of COVID-19. The fear was significantly influenced by these factors: the presence of serious food/drug allergic reactions (OR = 3.84, 95% CI: 1.40–10.52), received booster COVID-19 vaccine (OR = 0.20, 95% CI: 0.11–0.35), opinion on vaccination requirement (OR = 0.20, 95% CI: 0.11–0.35), viewpoint (OR = 0.23, 95% CI: 0.12–0.44) with scores ≥10, and positive attitude toward vaccination (OR = 0.21, 95% CI: 0.13–0.35). Our study revealed that a subset of medical staffs still harbor apprehension toward receiving the fourth dose of the new COVID-19 vaccine. Factors influencing this fear encompass allergic reactions, booster COVID-19 vaccine, as well as opinion, viewpoint, and attitude toward vaccination. Educating medical staffs on these factors may help mitigate their fear.

Understanding factors affecting Chinese medical staff’s fear of receiving the fourth dose of COVID-19 vaccine: A cross-sectional study in Taizhou