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Colorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide. While a close correlation between chronic  Helicobacter pylori  infection and CRC has been reported, the role of the virome has been overlooked. Here, we infected  Apc -mutant mouse models and C57BL/6 mice with  H. pylori  and conducted a comprehensive metagenomics analysis of  H. pylori -induced changes in lower gastrointestinal tract bacterial and viral communities. We observed an expansion of temperate phages in  H. pylori  infected  Apc+/1638Nmice at the early stage of carcinogenesis. Some of the temperate phages were predicted to infect bacteria associated with CRC, including  Enterococcus faecalis . We also observed a high prevalence of virulent genes, such as  flgJ ,  cwlJ , and  sleB , encoded by temperate phages. In addition, we identified phages associated with pre-onset and onset of  H. pylori -promoted carcinogenesis. Through co-occurrence network analysis, we found strong associations between the viral and bacterial communities in infected mice before the onset of carcinogenesis. These findings suggest that the expansion of temperate phages, possibly caused by prophage induction triggered by  H. pylori  infection, may have contributed to the development of CRC in mice by interacting with the bacterial community.

Gut virome profiling identifies an association between temperate phages and colorectal cancer promoted by Helicobacter pylori infection