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In healthy hosts the gut microbiota is restricted to gut tissues by several barriers some of which require MyD88-dependent innate immune sensor pathways. Nevertheless, some gut taxa have been reported to disseminate to systemic tissues. However, the extent to which this normally occurs during homeostasis in healthy organisms is still unknown. In this study, we recovered viable gut bacteria from systemic tissues of healthy wild type (WT) and MyD88 −/−  mice. Shotgun metagenomic-sequencing revealed a marked increase in the relative abundance of  L. johnsonii  in intestinal tissues of MyD88 −/−  mice compared to WT mice.  Lactobacillus johnsonii  was detected most frequently from multiple systemic tissues and at higher levels in MyD88 −/−  mice compared to WT mice. Viable  L. johnsonii  strains were recovered from different cell types sorted from intestinal and systemic tissues of WT and MyD88 −/−  mice.  L. johnsonii  could persist in dendritic cells and may represent murine immunomodulatory endosymbionts.

Identification of Gut Bacteria such as Lactobacillus johnsonii that Disseminate to Systemic Tissues of Wild Type and MyD88–/– Mice