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Telomeres are nucleotide repeat sequences located at the end of chromosomes that protect them from degradation and maintain chromosomal stability. Telomeres shorten with each cell division; hence telomere length is associated with aging and longevity. Numerous lifestyle factors have been identified that impact the rate of telomere shortening; high vitamin consumption has been associated with longer telomere length, whereas oxidative stress is associated with telomere shortening. In this paper, we sought to determine if a multivitamin mixture containing both vitamins and a blend of polyphenolic compounds, could reduce telomere shortening consequent to an oxidative stress (10 uM H 2 O 2  for 8 weeks) in a primary fibroblast cell culture model. Under conditions of oxidative stress, the median and 20 th  percentile telomere length were significantly greater ( p  &lt; 0.05), and the percentage of critically short telomeres (&lt;3000 bp) was significantly less ( p  &lt; 0.05) in cells treated with the multivitamin mixture at 4, 15 and 60 ug/ml compared to control (0 ug/ml). Median and 20 th  percentile telomere shortening rate was also reduced under the same conditions ( p  &lt; 0.05). Taken together, these findings demonstrate that the multivitamin mixture protects against oxidative stress-mediated telomere shortening in cell culture, findings which may have implications in human health.

A Multivitamin Mixture Protects against Oxidative Stress-Mediated Telomere Shortening