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The purpose of this investigation was to determine the effects of supplementing with 100 mg daily of 5-Hydroxytryptophan (5-HTP) on indices of body composition in exercise-trained men and women. Sixty-one subjects volunteered for this investigation. Forty-eight subjects were randomized into a treatment ( n  = 31, 12 male/19 female; 100 mg 5-HTP daily; CLEANMOOD ™ ) or a placebo ( n  = 17, six male/11 female; maltodextrin). Body composition was assessed pre- and post-treatment after eight weeks  via  a multi-frequency bioelectrical impedance device (InBody ®  270). Subjects were instructed to not change their training or eating habits; moreover, they were instructed to track their diet ∼2-3 days per week using a mobile app (MyFitnessPal). There were no changes in food intake (i.e. total energy intake or grams of macronutrients) between or within groups. Lean body mass, total body water, and % body fat did not change significantly in either group. Fat mass decreased significantly post versus pre in the 5-HTP group ( p  = 0.02) but did not change in the placebo group ( p  = 0.58). Moreover, changes in fat mass were significantly different between the 5-HTP and placebo group ( p  = 0.048). Based on the limited data from this investigation, daily supplementation with 100 mg of 5-HTP may affect body composition.

The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT