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Splenic abscesses are a rare medical entity with high mortality, with  Clostridium perfringens  being an exceptional pathogen. We present the first case describing an abscess of the spleen in a patient undergoing treatment with adalimumab, an anti-tumour necrosis factor commonly used in inflammatory bowel diseases. We describe the case of a 73-year-old woman, treated with adalimumab therapy, who was found to have a splenic abscess, caused by  C. perfringens . After antibiotic treatment and percutaneous drainage, the patient recovered both clinically and radiographically. We reviewed literature about  C. perfringens  splenic abscesses. In all cases identified, a splenectomy was performed. This is the first case description of splenic abscess caused by  C. perfringens  where a percutaneous drainage was performed, leading to complete recovery in our patient. This seems to indicate that a splenectomy is not necessary in all  C. perfringens  splenic abscesses.

Clostridium perfringens splenic abscess treated with percutaneous drainage and antibiotic therapy: a case report