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The series of ordered mutations that cause a specific cell to become cancerous is modeled so that the fraction of a risk population (e.g. White men) that has developed a specific cancer (e.g. melanoma) at any age can be calculated. The saturated model constructed and solved here is isomorphic to the physical model describing an ordered chain of radioactive nuclei decays with the exception that it allows for the possibility that a fraction of a risk population may be immune to developing a specific cancer

computational and mathematical methods in medicine

Evidence that Natural Immunity to Breast Cancer and Prostate Cancer Exists in the Majority of Their Risk Populations Is Predicted by a Novel, Inherently Saturated, Ordered Mutation Model