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To date, some studies revealed that HHIP gene polymorphisms may be associated with the risk of chronic obstructive pulmonary disease (COPD). Therefore, this meta-analysis explored the association between single-nucleotide polymorphisms (SNPs) of the human hedgehog interacting protein (HHIP) gene and susceptibility to COPD. Seven Chinese and English electronic databases were searched for eligible studies up to 30 May 2020. After the inclusion criteria were strictly followed, the Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of the included studies. The pooled odds ratio (OR) of the 95% confidence interval (CI) under four different genetic models was calculated to evaluate the association strength between the SNPs and COPD. Egger’s test was used to evaluate publication bias. This meta-analysis was registered at PROSPERO (CRD42021235708). In total, 12 studies involving 6623 COPD patients and 11,373 healthy controls were included. Regarding rs13118928 and rs1828591, an A &gt; G mutation increased the risk of COPD in Asian and Caucasian individuals, and the rs13147758 A &gt; G mutation and rs10519717 C &gt; T mutation increased the risk of COPD only in Asian people. No significant publication bias was observed. This meta-analysis provides a theoretical basis suggesting that HHIP gene polymorphisms may be associated with the risk of COPD.

Association of human Hedgehog interacting protein gene polymorphisms with the risk of chronic obstructive pulmonary disease: a meta-analysis