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While remaining incurable, median overall survival for MM now exceeds 5 years. Yet few studies have investigated how modifiable lifestyle factors influence survival. We investigate whether adiposity, diet, alcohol, or smoking are associated with MM-related fatality. We recruited 760 incident cases of MM via cancer registries in two Australian states during 2010–2016. Participants returned questionnaires on health and lifestyle. Follow-up ended in 2020. Flexible parametric survival models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for lifestyle exposures and risk of all-cause and MM-specific fatality. Higher pre-diagnosis Alternative Healthy Eating Index (AHEI) scores were associated with reduced MM-specific fatality (per 10-unit score, HR = 0.84, 95%CI = 0.70–0.99). Pre-diagnosis alcohol consumption was inversely associated with MM-specific fatality, compared with nondrinkers (0.1–20 g per day, HR = 0.59, 95%CI = 0.39–0.90; &gt;20 g per day, HR = 0.67, 95%CI = 0.40–1.13). Tobacco smoking was associated with increased all-cause fatality compared with never smoking (former smokers: HR = 1.44, 95%CI = 1.10–1.88; current smokers: HR = 1.30, 95%CI = 0.80–2.10). There was no association between pre-enrollment body mass index (BMI) and MM-specific or all-cause fatality. Our findings support established recommendations for healthy diets and against smoking. Higher quality diet, as measured by the AHEI, may improve survival post diagnosis with MM.

Modifiable lifestyle risk factors and survival after diagnosis with multiple myeloma