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We developed a Biomedical Knowledge Graph model that is phenotype and biological function‐aware through integrating knowledge from multiple domains in a Neo4j, graph database. All known human genes were assessed through the model to identify potential new risk genes for anterior cruciate ligament (ACL) ruptures and Achilles tendinopathy (AT). Genes were prioritised and explored in a case–control study comparing participants with ACL ruptures (ACL‐R), including a sub‐group with non‐contact mechanism injuries (ACL‐NON), to uninjured control individuals (CON). After gene filtering, 3376 genes, including 411 genes identified through previous whole exome sequencing, were found to be potentially linked to AT and ACL ruptures. Four variants were prioritised:  HSPG2 :rs2291826A/G,  HSPG2: rs2291827G/A,  ITGB2 :rs2230528C/T and  FGF9: rs2274296C/T. The rs2230528 CC genotype was over‐represented in the CON group compared to ACL‐R ( p  &lt; 0.001) and ACL‐NON ( p  &lt; 0.001) and the TT genotype and T allele were over‐represented in the ACL‐R group and ACL‐NON compared to CON ( p  &lt; 0.001) group. Several significant differences in distributions were noted for the gene‐gene interactions: ( HSPG2 :rs2291826, rs2291827 and  ITGB2: rs2230528) and ( ITGB2: rs2230528 and  FGF9 :rs2297429). This study substantiates the efficiency of using a prior knowledge‐driven  in silico  approach to identify candidate genes linked to tendon and ACL injuries. Our biomedical knowledge graph identified and, with further testing, highlighted novel associations of the  ITGB2  gene which has not been explored in a genetic case control association study, with ACL rupture risk. We thus recommend a multistep approach including bioinformatics in conjunction with next generation sequencing technology to improve the discovery potential of genomics technologies in musculoskeletal soft tissue injuries.

european journal of sport science

Application of an  in silico  approach identifies a genetic locus within  ITGB2,  and its interactions with  HSPG2 and FGF9,  to be associated with anterior cruciate ligament rupture risk