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This study examined the dose‐response effects of a 1‐year hybrid‐type, multicomponent interval training programme (DoIT) on various musculoskeletal fitness parameters in inactive overweight and obese adults in a gym setting. Ninety‐seven middle‐aged (44.8 ± 5.2 years) individuals with overweight/obesity (31.2 ± 5.7 kg/m 2 ) (66% female) were randomly assigned to the following groups: (i) no‐intervention control (CON,  n  = 29), (ii) DoIT performed once weekly (DoIT‐1,  n  = 24), (iii) DoIT performed twice weekly (DoIT‐2,  n  = 23) and (iv) DoIT performed thrice weekly (DoIT‐3,  n  = 21). DoIT was a time‐efficient, intermittent‐based, multicomponent exercise protocol using progressive loaded fundamental movement patterns with prescribed work‐to‐rest intervals (1:3–2:1) in a circuit format (2–3 rounds). Muscular strength, muscular endurance, flexibility, passive range of motion (PRoM), static balance and functional movement screen (FMS®) were assessed at baseline, 6 and 12 months following intervention. At post‐training, all exercise groups exhibited superior changes than CON in (i) muscular strength (+13%–38%,  p &lt;  0.001); (ii) muscular endurance (+42%–159%,  p  &lt; 0.001); (iii) flexibility (+12%–42%,  p  &lt; 0.001); (iv) PRoM (+6%–50%,  p  = 0.001–0.026); (v) static balance (+61%–163%,  p &lt;  0.001); and (vi) FMS (+18%–39%,  p  &lt; 0.001). Although a single exercise session/week improved musculoskeletal fitness, changes demonstrated a step‐wise improvement with two and three sessions/week suggesting a dose‐dependent response. The response rate to training was 100% for all exercise groups. These findings suggest that a multicomponent exercise approach incorporating bodyweight drills and resistance‐based alternative modes performed under real‐world conditions may improve several musculoskeletal fitness indicators in a dose‐dependent manner in inactive, middle‐aged adults with overweight/obesity.   Trial registration:  ClinicalTrials.gov identifier: NCT03759951.

european journal of sport science

Hybrid‐type, multicomponent interval training upregulates musculoskeletal fitness of adults with overweight and obesity in a volume‐dependent manner: A 1‐year dose‐response randomised controlled trial