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A simple and efcient one-pot approach for assembling some benzylidene-2-(benzo[ d ]thiazol-2-ylimino) thiazolidin-4-one derivatives utilizing Fe 3 O 4 –cysteine as an efficient catalyst  via  reaction between benzo[ d ]thiazol-2-amine, ammonium thiocyanate, chloroacetyl chloride, and aromatic aldehydes, in EtOH at 80°C, is reported. Minimize chemical waste, time-saving, simplify practical aspects besides the good functional group tolerance and easy separation of the nano-catalyst are the prominent features of the present methodology.  In vitro  antibacterial screening of synthesized compounds against  Staphylococcus aureus  ATCC 25923,  Staphylococcus epidermidis  ATCC 1446,  Bacillus cereus  ATCC 1247,  Escherichia coli  ATCC 1399, and  Pseudomonas aeruginosa  ATCC 1430 in different concentrations of the samples (200, 100, 50, 25, 12.5, 5.25, and 3.12 µg/ml) was done, and the lowest minimum inhibitory concentration, minimum bactericidal concentration, the zone inhibitory were measured, and biofilm formation was investigated.

One-pot reactions in the synthesis of thiazolidinone derivatives by nano-Fe 3 O 4 –cysteine catalyst