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To explore the curvilinear relationship between early stressful life events and future-oriented coping and whether the  HOMER1  (rs7713917) polymorphism can moderate the relationship between early life stress and two types of future-oriented coping, 14,675 Han Chinese people were surveyed. The relationship between the number of early stressful life events and future-oriented coping adhered to a quadratic curve.  HOMER1  polymorphisms moderated the relationship between the impact of early life stress and preventive coping (β = −0.02, 95% CI [−0.03, −0.01],  p  = 0.010), which was different from that of proactive coping (β = −0.01, 95% CI [−0.02, 0.01],  p  = 0.073). Individuals with the AA genotype who experienced a high impact of early life stress were more likely to use preventive coping compared with those who experienced a low level of early life stress, but they showed no difference in their proactive coping strategies. In contrast, individuals with the GA/GG genotype displayed higher vulnerability to environmental changes.

Vulnerability to early stressful life events: The moderating role of HOMER1 gene in the gene × environment interaction