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This is a cross-sectional study describing on Group B  Streptococcus( GBS) serotypes, virulence gene distribution and antimicrobial susceptibility in non-pregnant adults from two major hospitals on East-coast Malaysia. The patients’ clinical information was reviewed, while serotyping and virulence gene detection for the GBS isolates ( n  = 75) were conducted by PCR. GBS serotypes III and Ia were the most common, followed by serotypes II and IV. The majority of GBS ( n  = 65; 86.7%) presented with virulence genes such as  cyl E,  scp B,  lmb ,  hyl E and  bca.  Skin and soft tissue infection (SSTI) ( n  = 50; 66.7%) were the most common clinical diagnosis, with 90% of those diagnosed had underlying diabetes mellitus (DM). GBS serotype Ia and the virulence genes  cyl E and  scp B were common in SSTI. Good sensitivity towards penicillin, erythromycin and clindamycin were observed.

Serotypes, virulence and antimicrobial susceptibility of Group B Streptococci isolated from infections in non-pregnant adults in Malaysia