English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The current work reports the synthesis of novel hydrazones and bis-hydrazones containing 1,2,3-triazole moiety. Base-assisted aldol condensation of 4-acetyl-1,2,3-triazole  1a  (R = NO 2 ) and anisaldehyde ( 2 ) gave the corresponding chalcone  3  in 88% yield. 4-(1-(2-(2,4-Dinitrophenyl)hydrazineylidene)-3-(4-methoxyphenyl)allyl)-5-methyl-1-(4-nitrophenyl)-1 H -1,2,3-triazole ( 5 ) was synthesized in 85% yield from the reaction of  3  and 2,4-dinitrophenylhydrazine ( 4 ) in boiling ethanol in the presence of a catalytic amount of HCl. Condensation of  1b  (R = OMe) and  N -phenylhydrazinecarbothioamide( 6 ) in an acidic medium led to unexpected bis-hydrazones  8  rather than carbothioamide  7 . An acid catalyzed one-pot three-component reaction of carbohydrazide  9 , isatoic anhydride ( 10 ), and  1b,c  ( c : R = F,  d : R = H) gave the corresponding hydrazones  12a – 12c  in high yields, instead of the expected dihydroquinazolin-4(1 H )-ones  11 . The resulting hydrazones were fully characterized using different techniques including  1 H NMR,  13 C NMR, X-ray and elemental analysis. Antibacterial screening revealed that some of the synthesized heterocycles showed moderate activity against  Staphylococcus aureus  ATCC-47077 and  Listeria monocytogenes  ATCC-35152.

Synthesis and antibacterial evaluation of novel hydrazones and bis-hydrazones containing 1,2,3-triazole moiety