English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Alcohol and cannabis co-use is associated with negative alcohol consequences and alcohol use disorder. However, mediating and distal effects remain largely unstudied. Co-use is associated with alcohol use disorder/negative consequences even when accounting for drinking levels and personality, suggesting that other person-level characteristics may explain relations between co-use and negative outcomes. The current study tested whether internalizing symptoms, strong correlates of co-use and alcohol use disorder, explained the effect of co-use on alcohol use disorder. Data from adults ( N  = 353,000) in the 2008–2019 National Study on Drug Use and Health (NSDUH) were used. Analyses tested whether (1) substance use profiles reduced/dissipated the effect of co-use on alcohol use disorder, (2) internalizing symptoms (anxiety, depression) reduced/dissipated the effect of co-use on alcohol use disorder, and (3) internalizing symptoms were indirectly associated with alcohol use disorder via co-use. When accounting for frequency/quantity of use, co-use was still associated with higher odds of alcohol use disorder. Anxiety and depression were related to higher odds of an alcohol use disorder, however, the effect of co-use on higher odds of alcohol use disorder remained. Anxiety and depression scores were indirectly associated with higher odds of alcohol use disorder via co-use. Depressive and anxiety symptoms only accounted for a portion of the variance of co-use on alcohol use disorder, and there were indirect effects of internalizing symptoms through co-use. Future longitudinal research is needed to elucidate other person-level characteristics that drive associations between co-use and alcohol use disorder to target via interventions.

Hierarchical and mediated relations between internalizing symptoms, alcohol and cannabis co-use, and AUD