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This systematic review and meta-analysis focussed on insights into the relationship between  CACNA1C -rs1006737 and  ZNF804A -rs1344706 polymorphisms and cognitive performance in schizophrenia (SCZ) spectrum and bipolar disorder (BD) and provide some contributions for clinical practice. We searched the websites databases (PubMED, PsycINFO, Web of Science, EMBASE and Cochrane Library) using eligibility and exclusion criteria to capture all potential studies, based on PICO model and according to the PRISMA. Eight articles were included in this systematic review (five referring to  CACNA1C -rs1006737 and three related to  ZNF804A -rs1344706 polymorphisms), with a total of 5759 participants (1751 SCZ patients, 348 BD patients, 3626 controls and 34 first-degree relatives). The results demonstrated that the pooled effect of  CACNA1C -rs1006737 (risk difference RD = 0.08; 95% CI 0.02–0.15) was associated with altered cognitive function in patients with severe mental disorders, but not Z NF804A -rs1344706 polymorphism (RD = 0.19; 95% CI 0.09–0.48. The present meta-analysis provides evidence regarding slight association between  CACNA1C -rs1006737 polymorphisms and cognitive performance in severe mental disorders, indicating that cognitive impairment in severe mental disorders associated with the  CACNA1C  rs1006737 risk variants could only be expressed when interacting with environmental exposures. This study is registered with PROSPERO, number CRD42021246726.

the world journal of biological psychiatry

Impact of  ZNF804A  rs1344706 or  CACNA1C  rs1006737 polymorphisms on cognition in patients with severe mental disorders: A systematic review and meta-analysis