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Mycotoxins, especially carcinogenic aflatoxins (AFs), AFs B 1 -and-M 1 , are common contaminants of foodchains, damaging exposed hosts. We analyzed the effects of naturally-occurring levels of AFB 1 -and-AFM 1  on the rat pancreatic islets from various healthy rats and exposed for 24 and 48 h to 10–20 ng of each AF/mL. The exposed islets were analyzed for glucose-stimulated insulin secretion (GSIS), ATP content, caspase-3/7-and 9 and ROS load. This environmental toxic compound impaired islet cells quality, GSIS, ATP-and antioxidant capacity, proving sensitivity of pancreatic islets to AFs (moreso to AFB 1 ), thereby clarifying the possible underlying mechanisms of AFs in endocrine disorders, primarily type-2 diabetes.

Environmentally occurring aflatoxins B 1 and M 1 notifyably harms pancreatic islets