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Liver is susceptible to oxidative stress and inflammation. The effect of metformin on lipopolysaccharide (LPS)-mediated liver malfunction was investigated. Rats were grouped into (1) control, (2) LPS, (3–5) LPS as well as 50, 100, and 150 mg/kg of metformin for 5 weeks. LPS increased liver enzymes, IL-6, and malondialdehyde (MDA) ( p  &lt; 0.05 and  p  &lt; 0.001) whereas metformin reduced them ( p  &lt; 0.05 to  p  &lt; 0.001). LPS decreased total protein, albumin, total thiol, SOD and CAT ( p  &lt; 0.05 and  p  &lt; 0.001), and metformin attenuated the effect of LPS ( p  &lt; 0.05 to  p  &lt; 0.001). The protective effect of metformin is probably mediated via suppression of inflammation and improvement of oxidative stress status.

Ameliorative role of metformin on lipopolysaccharide-mediated liver malfunction through suppression of inflammation and oxidative stress in rats