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In the United States, buffalofish ( Ictiobus  spp.) are sporadically associated with sudden onset muscle pain and weakness due to rhabdomyolysis within 24 h of fish consumption (Haff disease). Previous genetic analyses of case-associated samples were unable to distinguish the three species of buffalofish that occur in the US,  Ictiobus cyprinellus  (bigmouth buffalo),  Ictiobus bubalus  (smallmouth buffalo), and  Ictiobus niger  (black buffalo). Ten events were investigated between 2010 and 2020 and demographic and clinical information was collected for 24 individuals. Meal remnants were collected from 5 of 10 events with additional associated samples ( n  = 24) collected from another five of 10 events. Low-coverage whole-genome sequencing (genome skimming) was used to identify meal remnants. Patients (26–75 years of age) ranged from 1–4 per event, with 90% involving ≥2 individuals. Reported symptoms included muscle tenderness and weakness, nausea/vomiting, and brown/tea-colored urine. Median incubation period was 8 h. Ninety-six percent of cases were hospitalized with a median duration of four days. The most commonly reported laboratory finding was elevated creatine phosphokinase and liver transaminases. Treatment was supportive including intravenous fluids to prevent renal failure. Events occurred in California (1), Illinois (2), Louisiana (1), New York (1), Mississippi (1), Missouri (2), New Jersey (1), and Texas (1) with location of harvest, when known, being Illinois, Louisiana, Mississippi, Missouri, Texas, and Wisconsin. Meal remnants were identified as  I. bubalus  ( n  = 4) and  I. niger  ( n  = 1). Associated samples were identified as  I. bubalus  ( n  = 16),  I. cyprinellus  ( n  = 5), and  I. niger  ( n  = 3). Time course, presentation of illness, and clinical findings were all consistent with previous domestic cases of buffalofish-associated Haff disease. In contrast to previous reports that  I. cyprinellus  is the causative species in US cases, data indicate that all three buffalofish species are harvested but  I. bubalus  is most often associated with illness.

Haff disease associated with consumption of buffalofish ( Ictiobus spp.) in the United States, 2010–2020, with confirmation of the causative species