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Background:  Chondroblastoma is a primary bone tumor typically arising from the intramedullary space of the epiphysis or epimetaphysis. A non-epiphyseal chondroblastoma is uncommon.  Case report:  An 11-year-old girl presented with an eccentric cortical osteolytic lesion in the distal femur metaphysis. The typical morphology, diffuse H3.3 K36M immunohistochemical expression and  H3F3B  point mutation ( c. 110A &gt; T ) unequivocally supported the diagnosis of chondroblastoma.  Discussion:  We described a non-epiphyseal cortical-based chondroblastoma involving the distal femur harboring the typical  H3F3B  mutation. Non-epiphyseal chondroblastoma may harbor the  H3F3B  mutation.

Distal Femoral Non-Epiphyseal Cortical Chondroblastoma Confirmed with H3F3B p. Lys36Met Mutation