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Objective:  Our aim was to assess mean platelet volume (MPV) and mean platelet volume to platelet count ratio (MPR) in the setting of late-onset sepsis (LOS) and their association with the type of bacteria causing LOS.  Study design:  The MPV and MPR levels were obtained at the onset of LOS and then assessed in intra/inter group analyses in preterm infants.  Results:  Overall, 136 preterm infants were enrolled. The MPV and MPR levels were higher during a LOS event ( P  &lt; 0.001). A MPV cutoff of &gt;9.2 was related with a sensitivity of 63% and a specificity of 73% for predicting LOS ( P  &lt; 0.001). A MPR cutoff of &gt;0.15 was related with a sensitivity of 88% and a specificity of 63% for predicting gram negative LOS ( P  &lt; 0.001).  Conclusion:  Elevated MPV values and MPR ratios may be helpful in assessing LOS.

Mean Platelet Volume and Mean Platelet Volume/Platelet Count Ratio Are Predictors of Late-Onset Sepsis in Preterm Infants: A Case-Control Study