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Background Previous studies have provided conflicting evidence implicating the IL-13 polymorphism and pediatric asthma. Thus, we performed a meta-analysis to combine and analyze the available studies to provide more accurate conclusions.  Methods:  A comprehensive retrieval in PubMed, EMBASE, Web of Science, and CNKI was performed up to February 05, 2020.  Results:  A total of 39 case-control studies including 15 studies with 4,968 cases and 7,091 controls were on +1923 C &gt; T, ten studies with 3,175 cases and 2,983 controls on -1112 C &gt; T, and 14 studies with 4,476 cases and 5,121 controls on +2044 A &gt; G were selected. Pooled data showed that the IL-13 + 1923 C &gt; T, −1112 C &gt; T and +2044 A &gt; G polymorphisms were significantly associated with risk of pediatric asthma. The IL-13 + 1923 C &gt; T (Asians and Africans), −1112 C &gt; T (Caucasians) and +2044 A &gt; G (Asians) polymorphisms were more frequently associated in these ethnic groups.  Conclusions:  Our pooled data indicated that IL-13 + 1923 C &gt; T, −1112 C &gt; T and +2044 A &gt; G polymorphisms were correlated with risk of pediatric asthma.

fetal and pediatric pathology

Association of +1923C &gt; T, -1112C &gt; T and +2044A &gt; G Polymorphisms in IL-13 Gene with Susceptibility to Pediatric Asthma: A Systematic Review and Meta-Analysis