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Objective:  We determined the prevalence and relationship of glycoprotein B (gB), glycoprotein N (gN), and glycoprotein H (gH) genotypes of cytomegalovirus (CMV) in CMV-associated thrombocytopenia (CAP).  Methods:  CMV gB, gN, and gH strains were determined by nested PCR and restriction length polymorphism from 24 CAP and 20 asymptomatic CMV infected infants.  Results:  The order of prevalence was gB1 (70.8%,17/24), gN4 (45.8%,11/24) and gH2 (54.2%,13/24). There was a greater prevalence of gB1(75.0%,15/20), gN4(50.0%,10/20) and gN2 (35.0%,7/20) in moderate to severe infection ( p  = 0.014 and  p  = 0.003). By logistic regression, gH2 ( p  = 0.031) had an elevated risk of thrombocytopenia. Reduced risks of thrombocytopenia were associated with gB2 ( p  = 0.020), gN1 ( p  = 0.018) and gN3 ( p  = 0.008). The most virulent were gB1 ( p  = 0.033) and gN2 ( p  = 0.038).  Conclusions:  There may be a potential association between the gH2 genotype of CMV and infantile thrombocytopenia.

Cytomegalovirus Genotype Distribution among Congenital and Perinatal Infected Patients with CMV-Associated Thrombocytopenia