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The chitin-glucan complex (CGC) consists of β-glucan and chitin with covalant bonds. CGC with biodegradable, biocompatible, antioxidant, and antibacterial properties is a powerful agent in wound healing.  Schizophyllum commune  is a source of these metabolite. This study aims to optimize the preparation of CGC nanofibers by electrospinning. Optimal conditions were selected for fabricating nanofibers (10% PVA solution, 2% CGC solution, 0.29 g gelatin, and 2.3 mL of acetic acid) with 17 kV, 900 rpm, and a feed rate of 0.3 mL/min. SEM showed uniform nanofibers with a diameter of 210 ± 71 nm and 56% porosity. FTIR investigates possible interactions between components. CGC/PVA/Gelatin nanofibers are hydrophilic. The tensile strength and Young’s modulus reached 4.223, 2.2092 Mpa, respectively. CGC/PVA/Gelatin nanofibers inhibit the growth of  E. coli  and  S. aureus  by 25% and 78% after 24 hours, respectively. These nanofibers are nontoxic to fibroblast cells and improve their proliferation and adhesion. CGC/PVA/Gelatin nanofibers were used to cover grade 2 burn wounds in male Wistar rats. Morphometric results showed that the wound healing rate is 86% in the nanofibers treated group (p&lt; 0.05) and 58% and 49% in the positive and negative control groups.  S. commune  CGC nanofibers can be used as wound dressings.

journal of natural fibers

Schizophyllum commune -derived Chitin Glucan Complex Wound Dressing: Antibacterial Activity and Wound Healing Properties in a Second Degree Burn Animal Model