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Chronic obstructive pulmonary disease (COPD) is a complex disease, and its pathogenesis is influenced by genetic factors. This study aimed to evaluate the role of  IL5RA  genetic variation in the risk of COPD. In this study, 498 patients with COPD and 498 normal controls were recruited. Subsequently, five SNPs (rs3804795, rs2290610, rs13097407, rs334782, and rs3856850) in the  IL5RA  gene were genotyped. Logistic analysis examined the association of five single nucleotide polymorphisms (SNPs) in  IL5RA  with the risk of COPD under various genetic models. Furthermore, the association between  IL5RA  and susceptibility to COPD was comprehensively analyzed with stratification based on age, sex, smoking, and alcohol consumption. Our study showed that  IL5RA  rs13097407 reduced susceptibility to COPD (OR = 0.43,  p  &lt; 0.001,  p  (FDR)&lt; 0.001). On the other hand, rs3856850 was associated with an increased risk of COPD (OR = 1.71,  p  = 0.002,  p  (FDR) = 0.002). Interestingly, the effect of  IL5RA  SNPs on susceptibility to COPD was found to be influenced by factors such as sex and smoking.  IL5RA  gene variants were significantly associated with susceptibility to COPD.

The Study of the Influence of IL5RA Variants on Chronic Obstructive Pulmonary Disease