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Meiosis is an important and highly conserved process that occurs during eukaryotic sexual reproduction. Diverse mechanisms are responsible for meiosis initiation among eukaryotes, and transcription factors have been established to have an important role in many species. However, the specific function of transcription factors in initiating meiosis in ciliates is unknown. Here we show that a putative Cys2His2 zinc finger-containing transcription factor encoded by the  ZFP1  gene is specifically expressed during sexual reproduction in  Tetrahymena thermophila . Meiosis is not initiated in the cells lacking  ZFP1 . Transcriptome sequencing analyses reveal that Zfp1 is required for the expression of many meiosis-specific genes. Our results indicate that Zfp1 could be a transcriptional activator required for meiosis initiation in  T. thermophila .

Zfp1, a Cys2His2 zinc finger protein is required for meiosis initiation in Tetrahymena thermophila