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Triclosan (TCS) is a synthetic broad-spectrum antimicrobial agent commonly used world-wide in a range of personal care and sanitizing products detected frequently in aquatic ecosystems. The aim of this study was to examine biochemical markers responses triggered by TCS in  Danio rerio  and in a native South American fish species ( Corydoras paleatus ). Further, an integrated approach comparing both test fish species was undertaken. These fish organisms were exposed to 100 or 189 µg TCS/L for 48 h. The activities of catalase (CAT), glutathione-s-transferase (GST), superoxide dismutase (SOD), and lipid peroxidation levels (LPO) and total antioxidant capacity against peroxyl radicals (ACAP) were determined in liver, gills, and brain. Acetylcholinesterase activity (AChE) was measured in the brain. Multivariate analysis showed that the most sensitive hepatic parameters were activities of GST and SOD for  C. paleatus  while LPO levels were for  D. rerio . In gills the same parameters were responsive for  C. paleatus  but CAT in  D. rerio . ACAP and GST activity were responsive parameters in brain of both species. Integrated biomarker responses (IBR) index demonstrated similar trends in both species suggesting this parameter might serve as a useful tool for quantification of integrated responses induced by TCS.

journal of toxicology and environmental health, part a

Oxidative stress responses after exposure to triclosan sublethal concentrations: an integrated biomarker approach with a native ( Corydoras paleatus ) and a model fish species ( Danio rerio )