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This study aims to investigate the genetic polymorphism in the interleukin-17F ( IL-17F ) (rs763780, 7488 A/G) gene in bipolar disorder (BD) and schizophrenia (SCZ) patients by comparing it with healthy controls considering clinical parameters. A sample of 107 patients with BD, 129 patients with SCZ, and 100 healthy volunteers were included. SCID-I was used to confirm the diagnosis according to DSM-IV-TR criteria. The Young Mania Rating Scale (YMRS) and the Hamilton Depression Rating Scale (HAM-D) were administered to BD patients. The Positive and Negative Symptoms Scale (PANSS) was applied to the patients with SCZ. PCR-RFLP was used to determine  IL-17F  gene polymorphism. Our results demonstrated that the distributions of the  IL-17F  genotype and the allele frequencies of BD patients were statistically significantly different from the control group. The AA genotype (OR: 0.283; 95% Cl: 0.140–0.573;  p &lt;.001) and A allele (OR: 0.333; 95% Cl: 0.171–0.646;  p =.001) frequencies were significantly higher in the control group than in the BD group. The  IL-17F  genotype and the allele frequency distributions of SCZ patients were not statistically significantly different from the control group. When comparing scale scores due to the  IL-17F  genotype distributions in patients with BD or SCZ, there was no statistically significant difference between the groups of  IL-17F  genotypes. In summary, whereas the  IL-17F  polymorphism may be associated with BD, this polymorphism was not related to SCZ.

Genetic polymorphism of IL-17F rs763780 contributes to the susceptibility to bipolar disorder but not to schizophrenia in the Turkish population